Measuring Breast Density with Breast CT

Understanding Breast Density

Dense breast tissue appears white on a mammogram- so do suspicious lesions and tumors.

The density of the tissue as well as the compression required for current standard mammography and tomosynthesis breast imaging could obscure abnormalities that may otherwise be further investigated if they were observed using these imaging modalities in non-dense breast tissue. Currently only a mammogram can diagnose and confirm breast density. Nearly half of all women age 40 and older who get mammograms are found to have dense breasts.

Given the prevalence of women with dense breast tissue and the limitations of mammography and tomosynthesis, the Company believes breast CT and its patented density measurement capability will not only revolutionize how breast density measurements will be taken in the future, but also how breast CT will contribute to the reduction of false-negative breast imaging results. With mammography, approximately 20% of breast cancers are missed that are present at the time of screening. In the future, women entering their breast cancer screening years may have a breast density measurement taken with breast CT to determine their individual screening protocols.

Measuring Breast Density with Breast CT

In Q1 2020 The United States Patent and Trademark Office issued U. S. Patent No. 10,548,549, entitled “Measuring Breast Density Using Breast Computed Tomography” to Izotropic Corporation. 

Principal Founder of Breast CT and Company Director,Dr. John Boone elaborates:

“Breast density is important for two reasons (1) women with denser breasts are thought to have a higher risk of breast cancer, and (2) breast cancer is harder to detect using 2D mammography in women with dense breasts. In the world of health care where “personalized medicine” is now a widely accepted priority, an accurate assessment of breast density then sets the stage for designing each individual woman’s breast cancer screening protocol. Historically, breast density is judged subjectively on two-dimensional mammograms by the interpreting radiologist using a four-point scale. We have shown that the truly 3D volume data sets that are produced using breast CT result in more accurate quantitative estimates of breast density, and this approach significantly outperforms mammography. Therefore, Breast CT may play an important role in quantifying breast density as a woman enters her breast cancer screening years.

We have also shown using realistic and comprehensive computer simulations that breast CT, owing to its three-dimensional nature, suffers far less in detection probability than two-dimensional mammography in women with dense breasts. Hence, breast CT or the more expensive and time-consuming breast MRI, are likely to be better screening and diagnostic tools in women with dense breasts than 2D mammography.”